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Faculty

Marc Y. Fink

Assistant Professor of Biomedical Sciences

B.A., City University of New York, Queens CollegePh.D., Mt. Sinai School of Medicine of New York University

Description

The research in my laboratory is focused on how oncogenes alter decision making of the breast cancer cell and ultimately contribute to tumorigenesis. HER2-positive breast cancers represent a major subset of this cancer type. Overexpression of the HER2 receptor tyrosine kinase drives enhanced and constitutive signaling at the cell membrane resulting in activation of several proliferative and anti-apoptotic pathways. Targeted therapeutic strategies have been developed (lapatinib and trastuzumab) and are currently used in the clinic to treat patients that harbor amplifications of HER2.  Many patients develop resistance to these targeted therapeutics but the mechanisms of these resistance programs still remain incompletely understood. The major projects in the laboratory focus on determining the signal transduction pathways of HER2 in breast cancer and the mechanisms underlying resistance.

Another area of research in the laboratory is induction of metastasis. Carcinoma cells undergo dramatic changes that allow them to discontinue growth as epithelial cells in a solid tumor and switch to a more mesenchymal morphology that is compatible with migration and invasion-two features that are crucial for metastasis. My laboratory is focused on understanding the signaling and gene regulation required for this transition.

Specialties

Cancer biology, cell biology, signal transduction, endocrinology

Publications

Co-author, Kant I, Narkar AN, Amendolara AR, Lang C, and Fink MY. HER2 Regulates Survival of Breast Cancer Cells Through p70S6K-mediated Inhibition of BAD (manuscript in preparation)

Co-author, Fink MY and Chipuk JE. Survival of HER2-positive Breast Cancer Cells:Receptor Signaling to Apoptotic Control Machinery (accepted  for publication to Genes and Cancer)

Co-author, Shimoni Y*, Fink MY* and Sealfon SC. (2010) Plato’s Cave Algorithm: Inferring Functional Signaling Networks from Early Gene Expression Shadows. PLos Computational Biology. 6(6): e1000828

*these authors contributed equally to this work

Co-author, Fink MY*, Pincas H*, Choi, S-G, Nudelman G, and Sealfon SC. (2010) Gonadotropin-Releasing Hormone Receptor-Mediated Signaling Network in LbT2 Cells: A Pathway-Based Web-Accessible Knowledgebase.  Molecular Endocrinology. 24(9): 1863-71

*these authors contributed equally to this work

Co-author, Chu TT, Fink MY, Mong JA, John G, Auger AP, GE Y, Sealfon SC. (2007) Effective Use of Microarrays in Neuroendocrine Research. Journal of Neuroendocrinology. 19(3): 145-61

Co-author, Ruf F, Fink MY, and Sealfon SC. (2003) Structure of the GnRH Receptor Stimulated Signaling Network: Insights from Genomics. Frontiers in Neuroendocrinology. 23(3): 181-99

Co-author, Gil OD, Sakurai T, Bradley AE, Fink MY, Cassella MR, Kuo JA, and Felsenfeld DP. (2003) Ankyrin Binding Mediates L1CAM Interactions with Static Components of the Cytoskeleton and Inhibits Retrograde Movement of L1CAM on the Cell Surface. Journal of Cell Biology. 162(4): 719-30

Lectures and Presentations

Fink MY, Haley JA, Lang C, Haley EK, Nudelman G, Zaslavsky E, and Haley JD. (2013) “Kinetic Analysis of the EMT Reveals Multiple Layers of Gene Regulation”. 2013 Meeting on Systems Biology: Networks (Cold Spring Harbor Laboratory)

Fink MY, Singh S, Cho Y, and Mestry D. (2012) RSK “Signaling in HER2-positive Breast Cancer Cells”. Program of the Annual Meeting of the American Association of Cancer Research (2163)

Fink MY, Sapre M, Singh S. (2010) “Development of a Systems Model of a Triple-Negative Breast Cancer Cell”. Annual Meeting of the American Society for Cell Biology

Fink MY, Rudkevich I, Gore AJ, Jiang K, Miller WL, and Sealfon SC. (2006) “Analysis of the Gonadotrope Receptorome: Network Modulation by Thyroid Hormone. Molecular Biology of the Cell 17” (Suppl) 1851.

Fink MY, Yuen T, Ruf F, and Sealfon SC. Convergence of PKC and ERK “Signaling in the Regulation of an Immediate Early Gene Program Induced by Gonadotropin-Releasing Hormone”. Program of the 87th Annual Meeting of the Endocrine Society. P2-87, San Diego, CA

Professional Affiliations

Member, American Society for Cell Biology

Member, American Association for Cancer Research

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