Luis R. Martinez
Assistant Professor of Biomedical Sciences
B.S., University of Puerto Rico; M.S., Long Island UniversityM.B.A., Pace UniversityPh.D., Albert Einstein College of Medicine
Luis R. Martinez, Ph.D., received his B.S. degree in Industrial Microbiology from the University of Puerto Rico-Mayagüez. He earned a M.S. degree at Long Island University (LIU) in Brooklyn, NY. His thesis project on the pathogenic fungus Cryptococcus neofomans thermal tolerance was conducted in Albert Einstein College of Medicine (EINSTEIN) in the Bronx, NY under the supervision of Dr. Arturo Casadevall. His master’s studies were supported by a NIH minority bridge to the doctorate award, which facilitated his externship at a research-oriented institution where he met mentors that encouraged him to pursue a career in science. This experience and his growing scientific curiosity led him to enroll in the Ph.D. program in the laboratory of Dr. Casadevall at EINSTEIN where he was responsible for characterizing biofilm formation in C. neoformans.
Upon successfully completing his Ph.D., Dr. Martinez joined the laboratory of Dr. Joshua D. Nosanchuk at EINSTEIN to extend his work on microbial pathogenesis and the biology of the immune system. In the course of his post-doctoral training supported by an NIH-Molecular Pathogenesis Training Grant, he developed the first infection model in methamphetamine (METH) exposed animals and was the first to describe the effect of METH on the host response to systemic challenge with a pathogen. Also, he successfully led a project that characterized the wound healing and antimicrobial properties of nitric oxide nanoparticles that have been licensed by a biotech company and are in advanced preclinical development. Notably, Dr. Martinez is a scholar from the Marine Biological Laboratory in Woods Hole, MA and Cold Spring Harbor Laboratory, NY.
Currently, he holds an Adjunct Assistant Clinical Professorship at EINSTEIN in conjunction with his tenure track Assistant Professorship at Long Island University-Post in Brookville, NY. He is currently funded with an NIH’s NIAID Research Scholar Development Award (K22) to further advance the development of his independent laboratory. The overarching goal of his research is to understand the effects of METH use on wound healing, skin and soft-tissue infections and microbial dissemination to the brain. Dr. Martinez is interested in training and preparing capable undergraduate and graduate students from all backgrounds including under-represented minorities as him and women who can successfully pursue careers in the biomedical sciences.
Microbiology, Immunology, Wound healing, Drug abuse on infection diseases
Co-author, Eugenin, E. A., J. M. Greco*, S. Frases, J. D. Nosanchuk, and L. R. Martinez. 2013. Methamphetamine alters blood brain barrier protein expression facilitating central nervous system infection by neurotropic Cryptococcus neoformans. J Infect Dis. Epub.
Co-author, Peerzada†, H., J. A. Gandhi†, A. J. Guimaraes, J. D. Nosanchuk, and L. R. Martinez. 2013. Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues. Immunobiology. Epub.
Co-author, Macherla†, C., D. A. Sanchez, M. Ahmadi*, E. M. Vellozzi, A. J. Friedman, J. D. Nosanchuk, and L. R. Martinez. 2012. Nitric oxide releasing nanoparticles for treatment of Candida albicans burn infections. Front Microbiol. 3:193.
Co-author, Han, G., L. N. Nguyen, C. Macherla†, Y. Chi, J. M. Friedman, J. D. Nosanchuk, and L. R. Martinez. 2012. Nitric oxide releasing nanoparticles accelerate wound healing by promoting fibroblast migration and collagen deposition. Am J Pathol. 180:1465-73.
Co-author, Prados-Rosales, R., A. Baena, L. R. Martinez, J. Luque-Garcia, R. Kalscheuer, U. Veeraraghavan, C. Camara, J. D. Nosanchuk, G. S. Besra, B. Chen, J. Jimenez, A. Glatman-Freedman, W. R. Jacobs Jr, S. A. Porcelli, and A. Casadevall. 2011. Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2 dependent-manner in mice. J Clin Invest. 121:1471-83.
American Society for Microbiology
Council on Undergraduate Research
Medical Mycology Society of America
Metropolitan Association of College and University Biologists
New York Academy of Science
Public Responsibility in Medicine and Research