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Faculty


Grace Rossi

Grace C. Rossi

Professor of Psychology

B.A., Susquehanna UniversityM.A., Hunter College, CUNYPh.D., The Graduate School, CUNY

Specialties

Brainstem Regions, Neuropsychology, Pain Tolerance in Cancer Patients, Pharmacological Characterization of the Endogenous Pain System

Publications

1. Marrone GF, Lu Z, Rossi G, Narayan A, Hunkele A, Marx S, Xu J, Pintar J, Majumdar S, Pan YX, Pasternak GW. Tetrapeptide Endomorphin Analogs Require Both Full Length and Truncated Splice Variants of the Mu Opioid Receptor Gene Oprm1 for Analgesia. ACS chemical neuroscience. 2016; 7(12):1717-1727. NIHMSID: NIHMS818065 PubMed [journal] PMID: 27648914, PMCID: PMC5177531

2. Grinnell SG, Ansonoff M, Marrone GF, Lu Z, Narayan A, Xu J, Rossi G, Majumdar S,  Pan YX, Bassoni DL, Pintar J, Pasternak GW. Mediation of buprenorphine analgesia  by a combination of traditional and truncated mu opioid receptor splice variants. Synapse (New York, N.Y.). 2016; 70(10):395-407. NIHMSID: NIHMS790429 PubMed [journal] PMID: 27223691, PMCID: PMC4980214

3. Marrone GF, Grinnell SG, Lu Z, Rossi GC, Le Rouzic V, Xu J, Majumdar S, Pan YX, Pasternak GW. Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(13):3663-8. PubMed [journal] PMID: 26976581, PMCID: PMC4822618

4. Arout CA, Caldwell M, Rossi G, Kest B. Spinal and supraspinal N-methyl-D-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia. Physiology & behavior. 2015; 147:364-72. PubMed [journal] PMID: 25982086

5. Lu Z, Xu J, Rossi GC, Majumdar S, Pasternak GW, Pan YX. Mediation of opioid analgesia by a truncated 6-transmembrane GPCR. The Journal of clinical investigation. 2015; 125(7):2626-30. PubMed [journal] PMID: 26011641, PMCID: PMC4563690

6. Xu J, Faskowitz AJ, Rossi GC, Xu M, Lu Z, Pan YX, Pasternak GW. Stabilization of  morphine tolerance with long-term dosing: association with selective upregulation of mu-opioid receptor splice variant mRNAs. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(1):279-84. PubMed [journal] PMID: 25535370, PMCID: PMC4291645

7. Xu J, Lu Z, Xu M, Rossi GC, Kest B, Waxman AR, Pasternak GW, Pan YX. Differential expressions of the alternatively spliced variant mRNAs of the µ opioid receptor gene, OPRM1, in brain regions of four inbred mouse strains. PloS one. 2014; 9(10):e111267. PubMed [journal] PMID: 25343478, PMCID: PMC4208855

8. Xu J, Xu M, Brown T, Rossi GC, Hurd YL, Inturrisi CE, Pasternak GW, Pan YX. Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action. The Journal of biological chemistry. 2013; 288(29):21211-27. PubMed [journal] PMID: 23760268, PMCID: PMC3774389

9. Xu J, Xu M, Rossi GC, Pasternak GW, Pan YX. Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1. Molecular pain. 2011; 7:9. PubMed [journal] PMID: 21255438, PMCID: PMC3057186

10. Rossi GC, Matulonis JE, Richelson E, Barbut D, Pasternak GW. Systemically and topically active antinociceptive neurotensin compounds. The Journal of pharmacology and experimental therapeutics. 2010; 334(3):1075-9. PubMed [journal] PMID: 20576795, PMCID: PMC2939665

11. Kest B, Smith SB, Schorscher-Petcu A, Austin JS, Ritchie J, Klein G, Rossi GC, Fortin A, Mogil JS. Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice. Neuroscience. 2009; 162(4):1255-64. PubMed [journal] PMID: 19460419

12. Klein G, Rossi GC, Waxman AR, Arout C, Juni A, Inturrisi CE, Kest B. The contribution of MOR-1 exons 1-4 to morphine and heroin analgesia and dependence.  Neuroscience letters. 2009; 457(3):115-9. PubMed [journal] PMID: 19429175

13. Pan YX, Xu J, Xu M, Rossi GC, Matulonis JE, Pasternak GW. Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. Proceedings of the National Academy of Sciences of the United  States of America. 2009; 106(12):4917-22. PubMed [journal] PMID: 19273844, PMCID: PMC2660730

14. Milo S, Ansonoff M, King M, Rossi GC, Zuckerman A, Pintar J, Pasternak GW. Codeine and 6-acetylcodeine analgesia in mice. Cellular and molecular neurobiology. 2006; 26(4-6):1011-9. PubMed [journal] PMID: 16868817

15. Israel Y, Kandov Y, Khaimova E, Kest A, Lewis SR, Pasternak GW, Pan YX, Rossi GC, Bodnar RJ. NPY-induced feeding: pharmacological characterization using selective  opioid antagonists and antisense probes in rats. Peptides. 2005; 26(7):1167-75. PubMed [journal] PMID: 15949635

16. Hadjimarkou MM, Singh A, Kandov Y, Israel Y, Pan YX, Rossi GC, Pasternak GW, Bodnar RJ. Opioid receptor involvement in food deprivation-induced feeding: evaluation of selective antagonist and antisense oligodeoxynucleotide probe effects in mice and rats. The Journal of pharmacology and experimental therapeutics. 2004; 311(3):1188-202. PubMed [journal] PMID: 15333676

17. Hopkins E, Rossi G, Kest B. Sex differences in systemic morphine analgesic tolerance following intrathecal morphine injections. Brain research. 2004; 1014(1-2):244-6. PubMed [journal] PMID: 15213009

18. Hadjimarkou MM, Khaimova E, Pan YX, Rossi GC, Pasternak GW, Bodnar RJ. Feeding induced by food deprivation is differentially reduced by opioid receptor antisense oligodeoxynucleotide probes in rats. Brain research. 2003; 987(2):223-32. PubMed [journal] PMID: 14499967

19. Shane R, Acosta J, Rossi GC, Bodnar RJ. Reciprocal interactions between the amygdala and ventrolateral periaqueductal gray in mediating of Q/N(1-17)-induced  analgesia in the rat. Brain research. 2003; 980(1):57-70. PubMed [journal] PMID:  12865159

20. Neilan CL, King MA, Rossi G, Ansonoff M, Pintar JE, Schiller PW, Pasternak GW. Differential sensitivities of mouse strains to morphine and [Dmt1]DALDA analgesia. Brain research. 2003; 974(1-2):254-7. PubMed [journal] PMID: 12742645

21. Hadjimarkou MM, Silva RM, Rossi GC, Pasternak GW, Bodnar RJ. Feeding induced by food deprivation is differentially reduced by G-protein alpha-subunit antisense probes in rats. Brain research. 2002; 955(1-2):45-54. PubMed [journal] PMID: 12419520

22. Abbadie C, Rossi GC, Orciuolo A, Zadina JE, Pasternak GW. Anatomical and functional correlation of the endomorphins with mu opioid receptor splice variants. The European journal of neuroscience. 2002; 16(6):1075-82. PubMed [journal] PMID: 12383236

23. Silva RM, Grossman HC, Rossi GC, Pasternak GW, Bodnar RJ. Pharmacological characterization of beta-endorphin- and dynorphin A(1-17)-induced feeding using G-protein alpha-subunit antisense probes in rats. Peptides. 2002; 23(6):1101-6. PubMed [journal] PMID: 12126737

24. Silva RM, Grossman HC, Hadjimarkou MM, Rossi GC, Pasternak GW, Bodnar RJ. Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. The Journal of pharmacology and experimental therapeutics. 2002; 301(2):513-8. PubMed [journal]  PMID: 11961051

25. Rossi GC, Pellegrino M, Shane R, Abbadie CA, Dustman J, Jimenez C, Bodnar RJ, Pasternak GW, Allen RG. Characterization of rat prepro-orphanin FQ/nociceptin((154-181)): nociceptive processing in supraspinal sites. The Journal of pharmacology and experimental therapeutics. 2002; 300(1):257-64. PubMed [journal] PMID: 11752124

26. Shane R, Lazar DA, Rossi GC, Pasternak GW, Bodnar RJ. Analgesia elicited by OFQ/nociceptin and its fragments from the amygdala in rats. Brain research. 2001; 907(1-2):109-16. PubMed [journal] PMID: 11430891

27. Silva RM, Hadjimarkou MM, Rossi GC, Pasternak GW, Bodnar RJ. Beta-endorphin-induced feeding: pharmacological characterization using selective  opioid antagonists and antisense probes in rats. The Journal of pharmacology and  experimental therapeutics. 2001; 297(2):590-6. PubMed [journal] PMID: 11303047

28. Mathis JP, Rossi GC, Pellegrino MJ, Jimenez C, Pasternak GW, Allen RG. Carboxyl terminal peptides derived from prepro-orphanin FQ/nociceptin (ppOFQ/N) are produced in the hypothalamus and possess analgesic bioactivities. Brain research. 2001; 895(1-2):89-94. PubMed [journal] PMID: 11259764

29. Silva RM, Rossi GC, Mathis JP, Standifer KM, Pasternak GW, Bodnar RJ. Morphine and morphine-6beta-glucuronide-induced feeding are differentially reduced by G-protein alpha-subunit antisense probes in rats. Brain research. 2000; 876(1-2):62-75. PubMed [journal] PMID: 10973594

30. Letchworth SR, Mathis JP, Rossi GC, Bodnar RJ, Pasternak GW. Autoradiographic localization of (125)I[Tyr(14)]orphanin FQ/nociceptin and (125)I[Tyr(10)]orphanin FQ/nociceptin(1-11) binding sites in rat brain. The Journal of comparative neurology. 2000; 423(2):319-29. PubMed [journal] PMID: 10867661

31. Stein JA, Znamensky V, Baumer F, Rossi GC, Pasternak GW, Bodnar RJ. Mercaptoacetate induces feeding through central opioid-mediated mechanisms in rats. Brain research. 2000; 864(2):240-51. PubMed [journal] PMID: 10802031

32. Pan YX, Xu J, Bolan E, Chang A, Mahurter L, Rossi G, Pasternak GW. Isolation and  expression of a novel alternatively spliced mu opioid receptor isoform, MOR-1F. FEBS letters. 2000; 466(2-3):337-40. PubMed [journal] PMID: 10682855

33. Pan YX, Xu J, Bolan E, Abbadie C, Chang A, Zuckerman A, Rossi G, Pasternak GW. Identification and characterization of three new alternatively spliced mu-opioid  receptor isoforms. Molecular pharmacology. 1999; 56(2):396-403. PubMed [journal]  PMID: 10419560

34. Pasternak KR, Rossi GC, Zuckerman A, Pasternak GW. Antisense mapping KOR-1: evidence for multiple kappa analgesic mechanisms. Brain research. 1999; 826(2):289-92. PubMed [journal] PMID: 10224306

35. Leventhal L, Silva RM, Rossi GC, Pasternak GW, Bodnar RJ. Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. The Journal of pharmacology and experimental therapeutics. 1998; 287(2):538-44. PubMed [journal] PMID: 9808678

36. Goldberg IE, Rossi GC, Letchworth SR, Mathis JP, Ryan-Moro J, Leventhal L, Su W,  Emmel D, Bolan EA, Pasternak GW. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. The Journal of pharmacology and experimental therapeutics. 1998; 286(2):1007-13. PubMed [journal] PMID: 9694962

37. Krzanowska EK, Rossi GC, Pasternak GW, Bodnar RJ. Potency ratios of morphine and  morphine-6beta-glucuronide analgesia elicited from the periaqueductal gray, locus coeruleus or rostral ventromedial medulla of rats. Brain research. 1998; 799(2):329-33. PubMed [journal] PMID: 9675330

38. Chang A, Emmel DW, Rossi GC, Pasternak GW. Methadone analgesia in morphine-insensitive CXBK mice. European journal of pharmacology. 1998; 351(2):189-91. PubMed [journal] PMID: 9687002

39. Burdick K, Yu WZ, Ragnauth A, Moroz M, Pan YX, Rossi GC, Pasternak GW, Bodnar RJ. Antisense mapping of opioid receptor clones: effects upon 2-deoxy-D-glucose-induced hyperphagia. Brain research. 1998; 794(2):359-63. PubMed [journal] PMID: 9622675

40. Leventhal L, Mathis JP, Rossi GC, Pasternak GW, Bodnar RJ. Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia. European journal of pharmacology. 1998; 349(1):R1-3. PubMed [journal] PMID: 9669488

41. Rossi GC, Perlmutter M, Leventhal L, Talatti A, Pasternak GW. Orphanin FQ/nociceptin analgesia in the rat. Brain research. 1998; 792(2):327-30. PubMed [journal] PMID: 9593974

42. Rossi GC, Mathis JP, Pasternak GW. Analgesic activity of orphanin FQ2, murine prepro-orphanin FQ141-157 in mice. Neuroreport. 1998; 9(6):1165-8. PubMed [journal] PMID: 9601687

43. Mathis JP, Goldberg IE, Rossi GC, Leventhal L, Pasternak GW. Antinociceptive analogs of orphanin FQ/nociceptin(1-11). Life sciences. 1998; 63(11):PL 161-6. PubMed [journal] PMID: 9747901

44. Leventhal L, Stevens LB, Rossi GC, Pasternak GW, Bodnar RJ. Antisense mapping of  the MOR-1 opioid receptor clone: modulation of hyperphagia induced by DAMGO. The  Journal of pharmacology and experimental therapeutics. 1997; 282(3):1402-7. PubMed [journal] PMID: 9316853

45. Rossi GC, Leventhal L, Bolan E, Pasternak GW. Pharmacological characterization of orphanin FQ/nociceptin and its fragments. The Journal of pharmacology and experimental therapeutics. 1997; 282(2):858-65. PubMed [journal] PMID: 9262352

46. Brown GP, Yang K, King MA, Rossi GC, Leventhal L, Chang A, Pasternak GW. 3-Methoxynaltrexone, a selective heroin/morphine-6beta-glucuronide antagonist. FEBS letters. 1997; 412(1):35-8. PubMed [journal] PMID: 9257684

47. Rossi GC, Su W, Leventhal L, Su H, Pasternak GW. Antisense mapping DOR-1 in mice: further support for delta receptor subtypes. Brain research. 1997; 753(1):176-9.  PubMed [journal] PMID: 9125445

48. Rossi GC, Leventhal L, Pan YX, Cole J, Su W, Bodnar RJ, Pasternak GW. Antisense mapping of MOR-1 in rats: distinguishing between morphine and morphine-6beta-glucuronide antinociception. The Journal of pharmacology and experimental therapeutics. 1997; 281(1):109-14. PubMed [journal] PMID: 9103486

49. King MA, Rossi GC, Chang AH, Williams L, Pasternak GW. Spinal analgesic activity  of orphanin FQ/nociceptin and its fragments. Neuroscience letters. 1997; 223(2):113-6. PubMed [journal] PMID: 9089686

50. Rossi GC, Brown GP, Leventhal L, Yang K, Pasternak GW. Novel receptor mechanisms  for heroin and morphine-6 beta-glucuronide analgesia. Neuroscience letters. 1996; 216(1):1-4. PubMed [journal] PMID: 8892377

51. Rossi GC, Leventhal L, Pasternak GW. Naloxone sensitive orphanin FQ-induced analgesia in mice. European journal of pharmacology. 1996; 311(2-3):R7-8. PubMed  [journal] PMID: 8891615

52. Standifer KM, Rossi GC, Pasternak GW. Differential blockade of opioid analgesia by antisense oligodeoxynucleotides directed against various G protein alpha subunits. Molecular pharmacology. 1996; 50(2):293-8. PubMed [journal] PMID: 8700136

53. Leventhal L, Cole JL, Rossi GC, Pan YX, Pasternak GW, Bodnar RJ. Antisense oligodeoxynucleotides against the MOR-1 clone alter weight and ingestive responses in rats. Brain research. 1996; 719(1-2):78-84. PubMed [journal] PMID: 8782866

54. Brooks AI, Standifer KM, Rossi GC, Mathis JP, Pasternak GW. Characterizing kappa3 opioid receptors with a selective monoclonal antibody. Synapse (New York, N.Y.).  1996; 22(3):247-52. PubMed [journal] PMID: 9132993

55. Rossi GC, Standifer KM, Pasternak GW. Differential blockade of morphine and morphine-6 beta-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein alpha subunits in rats. Neuroscience letters. 1995; 198(2):99-102. PubMed [journal] PMID: 8592651

56. Rossi GC, Pan YX, Brown GP, Pasternak GW. Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6 beta-glucuronide receptor. FEBS letters. 1995; 369(2-3):192-6. PubMed [journal] PMID: 7649256

57. Pan YX, Cheng J, Xu J, Rossi G, Jacobson E, Ryan-Moro J, Brooks AI, Dean GE, Standifer KM, Pasternak GW. Cloning and functional characterization through antisense mapping of a kappa 3-related opioid receptor. Molecular pharmacology. 1995; 47(6):1180-8. PubMed [journal] PMID: 7603458

58. Rossi GC, Pasternak GW, Bodnar RJ. Mu and delta opioid synergy between the periaqueductal gray and the rostro-ventral medulla. Brain research. 1994; 665(1):85-93. PubMed [journal] PMID: 7882023

59. Rossi G, Pan YX, Cheng J, Pasternak GW. Blockade of morphine analgesia by an antisense oligodeoxynucleotide against the mu receptor. Life sciences. 1994; 54(21):PL375-9. PubMed [journal] PMID: 8196473

60. Rossi GC, Pasternak GW, Bodnar RJ. Synergistic brainstem interactions for morphine analgesia. Brain research. 1993; 624(1-2):171-80. PubMed [journal] PMID: 8252389

61. Kiefel JM, Rossi GC, Bodnar RJ. Medullary mu and delta opioid receptors modulate  mesencephalic morphine analgesia in rats. Brain research. 1993; 624(1-2):151-61.  PubMed [journal] PMID: 8252387

62. Barr GA, Rossi G. Conditioned place preference from ventral tegmental injection of morphine in neonatal rats. Brain research. Developmental brain research. 1992; 66(1):133-6. PubMed [journal] PMID: 1600627

Affiliation

  • Post-Doctoral Fellowship, Memorial Sloan Kettering Cancer Center