LIU Pharmacy and Health Sciences Core facilities offer researchers technology, tools and expertise to facilitate their research and become competitive for extramural grant funding. Core facilities are accessible across departments and divisions.
The Flow Cytometry Core provides access to the high-performance multicolor CytoFLEX Flow Cytometry System for single tube sample and plate loader accompanied by CytExpert software for data analysis (Beckman Coulter, Life Sciences).
We provide flow cytometry training to members of the research community and students of the College of Pharmacy and Health Sciences. Investigators from other LIU-Brooklyn departments are welcome to our facility. We are dedicated to providing the best training possible to ensure the best results attainable. The technology aids in cell counting, detecting biomarkers in complex subpopulations, identification and isolation of cancer stem cells, and functional assays.
Location: Wet Lab Building, Cancer Research Center, Room 206.
Contact: Eun-Jung Park, PhD,
The Laboratory Animal Facility (LAF) operates as a research support facility for the College of Pharmacy and Health Sciences and other LIU-Brooklyn departments. This facility offers housing, resources and management to provide animal-based research. Support functions include daily animal husbandry and supervision. A part-time veterinarian and veterinary technician provide assistance and training of students in addition to disease prevention, diagnosis and control. Regulatory control is by the College of Pharmacy and Health Sciences Institutional Animal Care and Use Committee (IACUC).
The Analytical Core is equipped with advanced analytical instrumentation in support of pre-clinical drug development research, industrial drug development and compounding pharmacy activities. Capabilities of the Core include physico-chemical and materials characterization, solid-state properties of APIs/excipients and dosage forms, chemical characteristics, chemical stability and degradant identification and quantitation, and the manifestation of processing and environmental stress throughout processing and storage. The instrumentation enables analysis in three broad categories: chemistry and solid-state structural analyses (LC-MS, PXRD, computational software), energetics analysis (DSC/TGA, sorption, UV, FTIR), kinetic analysis (HPLC, dissolution, crystallizer), and micromeritics (particle size, microscopy).
The Manufacturing Core is equipped with tablet manufacturing capabilities from single station to 16 station tablet presses together with V-blender, roller compactor, fluid bed dryer (top and bottom), coating pan and a recently acquired melt extruder. This core unit will cater to the generic, brand, nutraceutical and cosmetic industry toward developing challenging products and assist in solving common problems with tablet picking, sticking and other issues. The Core will also serve as a training hub for students, pharmaceutical scientists and employees at government agencies.
The Structure-Based Molecular And Computational Drug Design Core is equipped with the Schrödinger Small Molecule Drug Discovery Suite used for in silico compound docking and analysis. Compounds can be evaluated de novo or using virtual libraries such as ZINC or Maybridge. The program suite includes built-in capabilities for molecular dynamics simulations with Desmond, residue scanning, homology model building, site map prediction, free energy perturbation (FEP) calculations, and ADME filtering. In addition to computational drug design, open source program suites such as Phenix, CCP4, COOT, XDS, and iMosfilm are available for macromolecular x-ray crystallography.
The Small Animal Imaging Facility is a state-of-the-art in vivo imaging resource dedicated to small animal research. Housing the Lumina LT system (Perkin-Elmer), this lab will provide accurate anatomical and molecular bioluminescent and fluorescent imaging. The imaging modalities offer unprecedented opportunities to study in vivo small animal models of disease, providing accurate assessment of disease initiation, progression and response to therapy. The lab will work with individual investigators to design experiments, imaging protocols (BL or F), and quantification techniques to meet individual needs.
The Animal Imaging Facility will operate with three aims:
To provide in vivo imaging capabilities for College of Pharmacy and Health Sciences researchers, other Brooklyn campus researchers and collaborators
To train new users and students in the theory of in vivo bioluminescence and fluorescence imaging and in the operation of our instruments
To conduct novel research examining in vivo and ex vivo imaging techniques for disease mechanisms and progression, and drug biodistribution studies
Location: Wet Lab Building, Cancer Research Center, Rooms 219
Contact: Avinash Kumar, Ph.D.
Join the LIU Community!
We can't wait to welcome you to Shark Nation.
The application process is quick and easy, but if you have
any questions, our admissions counselors are here to help.