Multicellular organisms on the earth start their life as a single cell, a zygote. The zygote undergoes tremendous times of cell division. Cells created from cell division generate different parts of the body. Although all the cells of multicellular organisms have the same set of genome, the cells differentiate to have different morphology and function, having different fates. What genes are involved in creating different fates of each cell? How are the expression and function of those genes regulated differentially? To answer these questions, I study the cell fate determination mechanisms in Arabidopsis root cells. As a postdoctoral researcher, at the University of Michigan in Ann Arbor, I studied the molecular mechanism of epidermal cell fate determination in Arabidopsis roots. And I am continuing the research on the fate determination of different types of cells.
Jae Hyo Song, Su-Hwan Kwak, Kyoung Hee Nam, John Schiefelbein, Myeong Min Lee (2019) QUIRKY regulates root epidermal cell patterning through stabilizing SCRAMBLED to control CAPRICE movement in Arabidopsis. Nature Communications 10 (1): 1744.
Su-Hwan Kwak, Sang-Kee Song, Myeong Min Lee and John Schiefelbein (2015) TORNADO1 regulates root epidermal patterning through the WEREWOLF pathway in Arabidopsis thaliana. Plant Signaling & Behavior 10(12) e1103407.
Sang-Kee Song, Su-Hwan Kwak, Soo Chul Chang, John Schiefelbein and Myeong Min Lee (2015) WEREWOLF and ENHANCER OF GLABRA3 are interdependent regulators of the spatial expression pattern of GLABRA2 in Arabidopsis. Biochemical and Biophysical Research Communications 467: 94-100.
Su-Hwan Kwak, Sang-Kee Song, Myeong Min Lee and John Schiefelbein (2015) ANGUSTIFOLIA mediates one of the multiple SCRAMBLED signaling pathways regulating cell growth pattern in Arabidopsis thaliana. Biochemical and Biophysical Research Communications 465 (3): 587-593.
Kwak SH, Woo S, Lee MM, Schiefelbein J (2014) Distinct signaling mechanisms in multiple development pathways by the SCRAMBLED receptor of Arabidopsis. Plant Physiology 166: 976-987.
Kwak SH, Schiefelbein J (2014) TRIPTYCHON, not CAPRICE, participates in feedback regulation of SCM expression in the Arabidopsis root epidermis. Plant Signaling & Behavior 9(11) e973815.
Kwak, S.-H. and Schiefelbein, J. (2009) Regulated accumulation of the SCRAMBLED receptor and position-dependent cell type patterning in Arabidopsis. Plant Signaling & Behavior 4:332-335.
Kwak, S.-H. and Schiefelbein, J. (2009) Regulated accumulation of the SCRAMBLED receptor and position-dependent cell type patterning in Arabidopsis. Plant Signaling & Behavior 4:332-335.
Schiefelbein, J., Kwak, S.-H., Wieckowski, Y., Barron, C. and Bruex, A. (2009) The gene regulatory network for root epidermal cell-type pattern formation in Arabidopsis. Journal of Experimental Botany 60:1515-1521.
Kwak, S.-H. and Schiefelbein, J. (2008) A feedback mechanism controlling SCRAMBLED receptor accumulation and cell-type pattern in Arabidopsis. Current Biology 18:1949-1954.
Kwak, S.-H. and Schiefelbein, J. (2008) Cellular pattern formation by SCRAMBLED, a leucine-rich repeat receptor-like kinase in Arabidopsis. Plant Signaling & Behavior 3:110-112.
Wang, S., Kwak, S.-H., Zeng, Q., Ellis, B.E., Chen, X.-Y., Schiefelbein, J. and Chen, J.-G. (2007) TRICHOMELESS1 regulates trichome patterning by suppressing GLABRA1 in Arabidopsis. Development 134:3873-3882.
Kwak, S.-H. and Schiefelbein, J. (2007) The role of the SCRAMBLED receptor-like kinase in patterning the Arabidopsis root epidermis. Developmental Biology 302:118-131.
Kwak, S.-H., Shen, R. and Schiefelbein, J. (2005) Positional signaling mediated by a receptor-like kinase in Arabidopsis. Science 307:1111-1113.
Kwak, S.-H. and Lee, S.H. (2002) The transcript-level-independent activation of ornithine decarboxylase in suspension cultured BY2 cells entering the cell cycle. Plant and Cell Physiology 43:1165-1170.
Kwak, S.-H. and Lee, S.H. (2001) The regulation of ornithine decarboxylase gene expression by sucrose and small upstream open reading frame in tomato (Lycopersicon esculentum Mill). Plant and Cell Physiology 42: 314-323.
Kwak, S.-H. and Lee, S.H. (1997) The requirements for Ca2+, protein phosphorylation, and dephosphorylation for ethylene signal transduction in Pisum sativum L. Plant and Cell Physiology 38: 1142-1149.
