Grazia Stagni
Professor of PharmaceuticsIACUC Chair
B.S., Università Degli Studi di Bologna (Italy)M.S., Ph.D., University of Texas at AustinLaurea (summa cum laude) in Pharmaceutical Chemistry and Technology, Universita’Degli Studi di Bologna, Bologna, Italy
grazia.stagni@liu.edu
Description
Dr. Stagni is a Professor of Pharmaceutics at the Arnold & Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY. She has a degree in Medicinal Chemistry and Pharmaceutical Technology (CTF) from the University of Bologna, Bologna, Italy, and a Master and PhD from the University of Texas at Austin. In 2000 she joined the Faculty at the Arnold & Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY. Research interests include pharmacokinetics and pharmacodynamic modeling, and the use of cutaneous microdialysis to study local and transdermal drug delivery via iontophoresis or passive delivery, modeling and prediction of skin concentration, and IVIVC for topical and transdermal delivery. Dr. Stagni teaches a number of courses at both the graduate and undergraduate level, mostly in the area of pharmacokinetics.
Specialties
Pharmacokinetics, intradermal microdialysis, transdermal and topical delivery (iontophoresis, microneedles, passive diffusion), development of methods for in-vitro/in-vivo correlation (IVIVC) of topical/transdermal drug products, pharmacodynamics
Research Interests:
Dr. Stagni’s group emphasis is on in vivo/ex vivo studies of percutaneous penetration, development of PK/PD and IVIVC models, dermal bioavailability, topical bioequivalence, and development of new topical/transdermal formulations.
Publications
Tamakuwala, M. and G. Stagni, Fingolimod Hydrochloride Gel for Dermatological Applications: Optimization of Formulation Strength, and Effect of Colloidal-oatmeal (Aveeno®) as Penetration Enhancer., AAPS PharmSciTech; Early On-line 2015; DOI: 10.1208/s12249-015-0415-9
Patel, H., Joshi, A., Joshi, A., and Stagni, G, Effect of Microporation on Passive and Iontophoretic Delivery of Diclofenac Sodium, Drug Dev Ind Pharm. Early On-line, 2015;
Patel, D., Joshi, A., Patel, H., Stagni, G., Development and in-vivo evaluation of Ondansetron gels for transdermal delivery; Drug Dev Ind Pharm.; 41(6):1030-6; 2015
Shukla, C., Bashaw, E.D., Stagni, G., Benfeldt, E., Applications of dermal microdialysis: a review., J. Drug Del. Sci. Tech., 24 (3) 259-269; 2014
Joshi, A., Stagni, G., Cleary, A., Patel, K., Weiss, D. S. and Hagins, M., Iontophoresis Successfully Delivers Dexamethasone Sodium Phosphate to Dermis as Measured by Microdialysis., J Pharm Sci Jan;103(1):191-6; 2014
Mannem, V., Nanjarapalle, C., Stagni, G., Iontophoresis of amoxicillin and cefuroxime: rapid therapeutic concentrations in skin., Drug Dev Ind Pharm. 40(3):325-329; 2014
Tre, E. S., Patel, C., Aghara, S., Yadav, C., Stagni, G., Optimization of perfusate pH to improve microdialysis recovery of lipophilic compounds., J Pharmacol Toxicol Methods, 66, 276-280; 2012
Juluru R, Shukla C, Yin H, Stagni G., Skin microdialysis-based estimation of systemic bioavailability fraction., J Pharm Sci 101(1):405-413; 2011
Patel M, Joshi A, Hassanzadeth H, Juluru R, Stagni G, Quantification of dermal and transdermal delivery of meloxicam gels in rabbits., Drug Dev Ind Pharm 37(5):613-617; 2011
Other Publications
Stagni, G., The role of Microdialysis in the evaluation of iontophoretic, and dermal/transdermal delivery systems; “Special Feature”; in “Probes”, Microdialysis Focus group Magazine, July 2014; AAPS
Lectures and Presentations
Joshi A. P., A. P. Joshi, H. H. Patel, G. Stagni’, “Verapamil Inhibits Menthol Induced Skin Penetration Enhancing Effects”; AAPS Annual Meeting, Oct. 24-29, 2015, Orlando, FL; Poster Number: R6325
Mehta, J and Stagni G “Assessment of Drug Disposition in Dermis: A Microdialysis Approach”; AAPS Annual Meeting, Oct. 24-29, 2015, Orlando, FL; Poster Number: R6330
Patel, A., Stagni, G, In Vitro Optimization of Etoposide Phosphate Iontophoresis and Effect of Microporation with Iontophoresis, AAPS Annual Meeting, Nov. 2-Nov. 6, 2014, San Diego, CA, 2014
Patel, H., Joshi, A., Joshi, A., Stagni, G, In Vivo Quantification of Etoposide Phosphate Iontophoresis and Microporation with Iontophoresis, AAPS Annual Meeting, Nov. 2-Nov. 6, 2014, San Diego, CA, 2014
Madala, H. R., Mehta, J., Stagni, G, Microdialysis is an Alternative to Conventional Sampling for In Vitro Permeability Studies, AAPS Annual Meeting, Nov. 2-Nov. 6, 2014, San Diego, CA, 2014
Mehta, J., Joshi, A., Stagni, G., Pharmacokinetics of Ranitidine in Rabbit Skin and Plasma, AAPS Annual Meeting, Nov. 2-Nov. 6, 2014, San Diego, CA, 2014
Patel, H., Joshi, A., Stagni, G, Pharmacokinetics of Theophylline in Rabbit Skin and Plasma following Oral Administration, AAPS Annual Meeting, Nov. 2-Nov. 6, 2014, San Diego, CA, 2014
Patel, H., Joshi, A., Stagni, G, Skin Pharmacokinetics: Continuous versus Intermittent Microdialysis., AAPS Annual Meeting, Nov. 2-Nov. 6, 2014, San Diego, CA, 2014
Tamakuwala, M., Stagni, G, Fingolimod Hydrochloride Topical Gels Reduces
Inflammation in an Animal Model of Atopic Dermatitis, AAPS Annual Meeting, Nov. 2-Nov. 6, 2014, San Diego, CA, 2014
Tamakuwala, M., Stagni, G, To Evaluate In Vivo Anti-atopic Efficacy of Optimized Fingolimod Hydrochloride Topical Gel in DNCB Induced Hairless Mouse Model Using EASI Intensity Index Score, AAPS Annual Meeting, Nov. 2-Nov. 6, 2014, San Diego, CA, 2014
D. Patel, A. Joshi, and G. Stagni, Microporation Reduces Lag Time and Enhances Transdermal Delivery of an Ondansetron Gel Containing Camphor as Penetration Enhancer, AAPS Annual Meeting, , Nov. 11-14, 2013, S. Antonio, TX, 2013
D. Patel, A. Joshi, and G. Stagni, In-vivo Effect of Camphor and Isopropyl Myristate on Dermal and Transdermal Delivery of an Ondansetron gel;, AAPS Annual Meeting, , Nov. 11-14, 2013, S. Antonio, TX, 2013
H. Patel, A. Joshi, and G. Stagni;, A Novel Approach to Deliver Etoposide Phosphate by Evaluating Pharmacokinetics in a Rabbit Model Following Iontophoresis;, AAPS Annual Meeting, , Nov. 11-14, 2013, S. Antonio, TX, 2013
M. Tamakuwala and G. Stagni, Fingolimod Hydrochloride Gel for Dermatological Applications: Optimization of Formulation Strength;, AAPS Annual Meeting, , Nov. 11-14, 2013, S. Antonio, TX, 2013
J. Mehta and G. Stagni, In Vitro Evaluation of Glycerin as Solvent for Iontophoretic Delivery of Diphenhydramine Hydrochloride (DPH);, AAPS Annual Meeting, , Nov. 11-14, 2013, S. Antonio, TX, 2013
H. H. Patel, A. P. Joshi, A. P. Joshi, G. Stagni;, Effect of Microporation on the Dermal and Transdermal Delivery of Diclofenac Sodium (DS) Gel;, AAPS Annual Meeting, , Oct. 15-18, 2012, Chicago, IL, 2012
H. H. Patel, A. P. Joshi, A. P. Joshi, G. Stagni, Effect of Microporation on Iontophoretic Delivery of Diclofenac Sodium (DS) in Rabbit Dermis and Plasma;, AAPS Annual Meeting, , Oct. 15-18, 2012, Chicago, IL, 2012
D. R. Patel, G. Stagni;, Evaluation of Different Penetration Enhancers for Transdermal Delivery of an Ondansetron Gel;, AAPS Annual Meeting, , Oct. 15-18, 2012, Chicago, IL, 2012
J. M. LaFond, G. Stagni;, In Vitro Permeability and Retention Studies of a Topical Gel Formulation of Voriconazole;, AAPS Annual Meeting, , Oct. 15-18, 2012, Chicago, IL, 2012
A. Joshi, K. Patel, M. Hagins, G. Stagni;, Evaluation of Passive and Iontophoretic Delivery of Dexamethasone Sodium Phosphate in Rabbit Skin by Microdialysis;, AAPS Annual Meeting, , Oct. 23-27, 2011, Washington, DC, 2011
C. Nanjarapalle, G. Stagni, Iontophoresis of Cefuroxime Reaches Therapeutic Concentrations In Rabbit Skin;, AAPS Annual Meeting, , Oct. 23-27, 2011, Washington, DC, 2011
Books/Chapters
Stagni G. 2011. Cutaneous Microdialysis. In Dermatokinetics of Theraputic Agents, Murthy NS, Ed; Boca Raton, London, New York: CRC Press, Taylor & Francis Group. pp 131-147.
Grants/Contracts
2005-2008 Transport Pharmaceuticals, Inc., 40 Speen Street, Suite 402 Framingham, MA 01701 for the project: “Study of Dermis Pharmacokinetics of Acyclovir from Different Iontophoretic Formulations”
Honors/Awards
2000 AACP New Investigators Program Award for the project: “In vivo investigation of transdermal iontophoretic delivery of drugs via microdialysis sampling in dermis”
Professional Affiliations
American Association of Pharmaceutical Scientists (since 1989)
